A Flexible Enterprise Needs an Adaptable eBusiness Architecture in Order to Satisfy Naturally Evolving Requirements

Standards for exchange of purchasing information, such as ANSI X-12 for EDI, have been used by large industries (e.g. retail and auto) for almost 30 years. Newer web-based tools and new standards hold the promise of reduced cost and wider applicability. For many small to medium sized enterprises, the cost and rigidity of existing tools out weight the prospective gains, which must be amortised over comparatively few transactions. In this paper, we describe the development of an N-tiered, object-oriented, architecture for interacting with suppliers based on emerging web tools. We explore the ways in which the project was required to adapt to existing purchasing systems and the ways that the project evolved during its development. We identify patterns in the inevitable evolution of requirements during the implementation, and we describe the ways that the architecture facilitated the satisfaction of these changing requirements. By analysing the major “transition points” during the development, we attempt to document the fundamental nature of evolving requirements and the need to explicitly reflect them in adaptable e-business architectures

False in Name Only-Gastroduodenal Artery Pseudoaneurysm in a Recurrently Bleeding Patient: Case Report and Literature Review.

INTRODUCTION: Although the diagnosis of visceral pseudoaneurysm is unusual, it requires emergent attention due to the risk of rupture. We describe a 70-year old man with a gastroduodenal artery (GDA) pseudoaneurysm manifest as recurrent hæmorrhage. AREAS COVERED: We highlight the possible ætiologies, clinical presentations, diagnostic tools and treatment options for this condition. In this instance, the patient was successfully treated by selective angio-embolization. EXPERT COMMENTARY: A visceral pseudoaneurysm should be considered in patients with abdominal pain and GI hæmorrhage. At present, angio-embolization is first-line therapy

Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research

Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models that can be used to understand the underlying molecular pathology. Recently, there has been a surge of interest in the use of patient-derived cells, due to the development of induced pluripotent stem cells and their subsequent differentiation into neurons and glia. Access to patient cell lines carrying the relevant mutations is a limiting factor for many centres wishing to pursue this research. We have therefore generated an open-access collection of fibroblast lines from patients carrying mutations linked to neurological disease. These cell lines have been deposited in the National Institute for Neurological Disorders and Stroke (NINDS) Repository at the Coriell Institute for Medical Research and can be requested by any research group for use in in vitro disease modelling. There are currently 71 mutation-defined cell lines available for request from a wide range of neurological disorders and this collection will be continually expanded. This represents a significant resource that will advance the use of patient cells as disease models by the scientific community

The Triggerless Data Acquisition System of the XENONnT Experiment

The XENONnT detector uses the latest and largest liquid xenon-based timeprojection chamber (TPC) operated by the XENON Collaboration, aimed atdetecting Weakly Interacting Massive Particles and conducting other rare eventsearches. The XENONnT data acquisition (DAQ) system constitutes an upgraded andexpanded version of the XENON1T DAQ system. For its operation, it reliespredominantly on commercially available hardware accompanied by open-source andcustom-developed software. The three constituent subsystems of the XENONnTdetector, the TPC (main detector), muon veto, and the newly introduced neutronveto, are integrated into a single DAQ, and can be operated both independentlyand as a unified system. In total, the DAQ digitizes the signals of 698photomultiplier tubes (PMTs), of which 253 from the top PMT array of the TPCare digitized twice, at $\times10$ and $\times0.5$ gain. The DAQ for the mostpart is a triggerless system, reading out and storing every signal that exceedsthe digitization thresholds. Custom-developed software is used to process theacquired data, making it available within $\mathcal{O}\left(10\text{ s}\right)$for live data quality monitoring and online analyses. The entire system withall the three subsystems was successfully commissioned and has been operatingcontinuously, comfortably withstanding readout rates that exceed $\sim500$ MB/sduring calibration. Livetime during normal operation exceeds $99\%$ and is$\sim90\%$ during most high-rate calibrations. The combined DAQ system hascollected more than 2 PB of both calibration and science data during thecommissioning of XENONnT and the first science run.<br

Training Students to Intervene in Information Systems Ingerently Involves Organizational and Technology Skill Acquisition

The radical restructuring in enterprises caused by both global competition and technological innovation has created a new class of problems requiring a synthesis of organizational and technological skills. This class of problems is of central importance to all enterprises today and is critical to Small Medium Enterprises (SMEs). In this paper we explore our hypothesis that these problems exist and can be meaningfully identified and attacked by both university researchers and managers within enterprises. We further hypothesize that it is possible to design a program of training that prepares individuals to tackle these problems in real world situations by teaching both organizational and technology skills within a single program. We present case history data from four separate training programs that we have conducted along these lines in order to evaluate our hypotheses. Our data include the course structure, evaluations from students, professors, and industry partners as well as evaluations of the experiences of our students while applying their new skills in solving problems at a participating enterprises site

MagicSox: An E-Textile IoT System to Quantify Gait Abnormalities

The global society is increasingly facing the challenges that reduce mobility, quality of life, and independence. Gait disorders are often both a result of, and predictor of further issues, tied to the 15 million stroke patients annually worldwide. These individuals face a number of gait abnormalities including drop foot that is a pathological condition, limiting patients\u27 ability to lift the foot from the ground during the swing phase of walking. In this research work, we introduce a novel smart textile system, MagicSox that is woven with multiple sensors distributed over the surface of the foot. The overarching goal of MagicSox is to quantify the gait abnormalities in remote settings such as patients\u27 homes so that clinicians and physical therapists can assess their patients on daily basis. The paper provides a detailed architecture of MagicSox that leverages the computing and communication capabilities of a modern Internet of Things (IoT) processor, the Intel Curie. We have developed an Android smart phone app that uses Bluetooth low energy (BLE) and automates the multi-sensor data collection from MagicSox. In terms of signal processing of wearable sensor data, we adopted multiplication of backward differences (MOBD) to analyze the multi-modal time series data to distinguish drop foot events from normal walking cycles. We pursued a usability study on 12 healthy participants who were asked to walk normally and also to simulate drop foot cycles. We developed support vector machine (SVM) classifiers to analyze the data. The classification resulted in the accuracy of drop foot detection varying from 73:38% - 99:02%. The promising results now encourage us to evaluate MagicSox on stroke patients in future studies

Ecology of small mammals in a Brazilian rural area

Submitted by Sandra Infurna ([email protected]) on 2019-10-10T12:59:30Z No. of bitstreams: 1 RosanaGentile_CarlosEGrelle_etal_IOC_1999.pdf: 2843021 bytes, checksum: 268ca81658bd9f1401cda77392967271 (MD5)Approved for entry into archive by Sandra Infurna ([email protected]) on 2019-10-10T13:06:33Z (GMT) No. of bitstreams: 1 RosanaGentile_CarlosEGrelle_etal_IOC_1999.pdf: 2843021 bytes, checksum: 268ca81658bd9f1401cda77392967271 (MD5)Made available in DSpace on 2019-10-10T13:06:33Z (GMT). No. of bitstreams: 1 RosanaGentile_CarlosEGrelle_etal_IOC_1999.pdf: 2843021 bytes, checksum: 268ca81658bd9f1401cda77392967271 (MD5) Previous issue date: 1999Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Ecologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Ecologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Ecologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ, Brasil.Asmall mammal study was carried out in Pampanao valley, Sumidouro, State of Rio de Janeiro, Brazil,from June 1991 to July 1996. The area was characterised by small rmal propelties with vegetable plantations, pasture lands and small forest fragments. Small mammals were captured in seven line transects along the valley. Eleven small mammal species were captured: the didelphid marsupials Didelphis aurita, Philander !renata and Monodelphis americana, and the rodents Nectomys squamipes, Akodol/ cursor, OligOlyzomys nigripes, Bolomys lasiurus, Oecomys concolor (Sigmodontinae), Rattus rattus (Murinae), Proechimys iheringi and Euryzygomatomys guiara (Echimyidae). The heterogeneous habitat configuration probably allowed the occurrence of marsupials and more rodent species when compared to studies in monocu!ture areas

The strategies to reduce iron deficiency in blood donors randomized trial: design, enrolment and early retention.

BACKGROUND AND OBJECTIVES: Repeated blood donation produces iron deficiency. Changes in dietary iron intake do not prevent donation-induced iron deficiency. Prolonging the interdonation interval or using oral iron supplements can mitigate donation-induced iron deficiency. The most effective operational methods for reducing iron deficiency in donors are unknown. MATERIALS AND METHODS: ‘Strategies To Reduce Iron Deficiency’ (STRIDE) was a two-year, randomized, placebo-controlled study in blood donors. 692 donors were randomized into one of two educational groups or one of three interventional groups. Donors randomized to educational groups either received letters thanking them for donating, or, suggesting iron supplements or delayed donation if they had low ferritin. Donors randomized to interventional groups either received placebo, 19-mg or 38-mg iron pills. RESULTS: Iron deficient erythropoiesis was present in 52.7% of males and 74.6% of females at enrolment. Adverse events within 60 days of enrolment were primarily mild gastrointestinal symptoms (64%). The incidence of de-enrolment within 60 days was more common in the interventional groups than in the educational groups (P = 0.002), but not more common in those receiving iron than placebo (P = 0.68). CONCLUSION: The prevalence of iron deficient erythropoiesis in donors enrolled in the STRIDE study is comparable to previously described cohorts of regular blood donors. De-enrolment within 60 days was higher for donors receiving tablets, although no more common in donors receiving iron than placebo